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“This technology has shown it can expedite the detection of candidemia,” said Henry Ford study co-author
In addition to speed, the use of the T2MR platform provided increased certainty to the identification of Candida infections. Consistent with the performance of blood culture and T2MR published in other studies, the Candida species was definitively identified in 93% of patients after implementation of T2MR and in only 57% of patients prior to implementation of T2MR. Prior to implementation of the
“In our inaugural publication, we are excited to highlight innovative work done by antimicrobial stewardship clinicians to provide optimal care to their patients and be better stewards of antimicrobials,” said
The authors also identified an additional clinically relevant improvement in patient outcomes after the implementation of T2MR: a significant reduction of Candida ocular involvement from 30% to 12% was observed. The authors point out this could be associated with improved sensitivity of T2MR or due to improved timeliness of patient management by T2MR.
Although the study was not adequately powered to evaluate reduction in patient mortality rates, the authors note that appropriately treating patients within 24 hours of the onset of disease is proven to reduce mortality rates from 41% to below 16%. T2MR is the only diagnostic method presented in this study with the speed and accuracy necessary to enable therapeutic decisions that achieve this reduction in mortality.
“I expected that T2MR platform’s direct-from-whole-blood technology would be the biggest breakthrough in candidemia management in decades and these clinical data demonstrate the promise of culture independent diagnostics,” said
About the sepsis-causing pathogen Candida
Candida is one of the deadliest sepsis-causing pathogens with a startling mortality rate of approximately 40% among patients receiving current standard of care. It is one of the leading hospital-acquired bloodstream infections in
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Darlene Deptula-Hicks, T2 Biosystems
SVP & Chief Financial Officer
Amy Phillips, Feinstein Kean Healthcare
Chris Brinzey, Westwicke Partners