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                         August 31, 2023

       John Sperzel
       President, Chief Executive Officer and Chairman of the Board
       T2 Biosystems, Inc.
       101 Hartwell Avenue
       Lexington, MA 02421

                                                        Re: T2 Biosystems, Inc.
Statement on Form S-3
                                                            Filed August 24,
                                                            File No. 333-274182

       Dear John Sperzel:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Conlon
Danberg at 202-551-4466 with any questions.


                         Division of Corporation Finance

                         Office of Industrial Applications and

       cc:                                              Evan Smith, Esq.