October 22, 2018

Michael T. Gibbs, Esq.
General Counsel
T2 Biosystems, Inc.
101 Hartwell Ave.
Lexington, MA 02421

       Re: T2 Biosystems, Inc.
           Registration Statement on Form S-3
           Filed October 15, 2018
           File No. 333-227847

Dear Mr. Gibbs:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Tim Buchmiller at (202) 551-3635 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Electronics and Machinery
cc:    Johan V. Brigham, Esq.